Schwann cells make myelin in the peripheral nervous system (PNS: nerves) and oligodendrocytes in the central nervous system (CNS: brain and spinal cord). In the PNS, one Schwann cell forms a ...

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a rare autoimmune disease of the central nervous system. According to estimates, 1 to 3 in 100,000 people are affected.

Oligodendrocytes generate myelin. Hoffman, a nun and chemistry professor who earlier this year retired from the University of Portland after 35 years to lead her convent, began collaborating with ...

The investigators focused on brain cells called human oligodendrocyte progenitor cells (OPCs), which can transform into the cells that generate myelin: oligodendrocytes. However, in MS, inflammation ...

How oligodendrocytes use fatty acid metabolism as an energy reserve to maintain axonal function and myelin stability when ...

Donor-derived MBP+ oligodendrocytes and myelin (red) are evident in the corpus callosum, while donor-derived GFAP+ astrocytes (green) predominate on the striatal side. Scale bar, 1 mm (a-c), 100 ...

Causing mice to express more C1QL1, however, led to increased numbers of oligodendrocytes and more myelination upon drug withdrawal, suggesting that C1QL1 helps to restore the damaged myelin layer.

This study uncovers the ketogenic diet's effects on the microbiome, revealing its potential to mitigate autoimmune diseases ...

where they inhibit oligodendrocyte myelination. Thus, they represent potential molecular targets to promote remyelination in demyelinating disease such as Multiple Sclerosis of Leukodystrophies. While ...

In some cases, the body also attacks another protein known as myelin oligodendrocyte glycoprotein. This activates other parts of the immune system and causes inflammation and damage to myelin.

Myrtelle’s FIH trial utilizes the Company’s proprietary rAAV vector to directly target oligodendrocytes, the brain cells affected in CD which are responsible for producing myelin – the ...