Using unnatural base pairs, researchers have site-specifically biotinylated RNA, allowing them to immobilize an aptamer on a chip and detect its interaction with a target protein. Experiments with ...

While antisense oligonucleotide and aptamer drugs have been on the market ... employed to fight against the COVID-19 pandemic that RNA-based therapeutics attracted the attention of the general ...

Knowing that von Willebrand Factor (VWF) plays a central role in thrombosis, researchers developed an RNA aptamer that inhibits VWF, and an antidote oligonucleotide that reverses its activity. “We ...

A research team has developed an RNA-based sensor platform that can regulate ... for sensors that require high selectivity. When an aptamer binds to its target, it triggers a structural change ...

A small molecule-type ligand blocked cleavage by binding with RNA aptamer sequences, thereby retaining intact mRNA and inducing transgenic expression. The Y-shaped structure of aptamers could ...

The AptaFluor SAH Methyltransferase Assay uses a highly sensitive RNA aptamer that is capable of directly detecting SAH. The sensitivity of the aptamer (measures SAH at concentrations below 10 nM ...

Scientists at Aptadir transformed these RNA molecules into a drug that takes the shape of an aptamer – single-stranded molecules that bind to targets. “In order to make this suitable for clinical ...

In this Q&A, learn more about how Heonjoon Lee, fifth year biomedical engineering PhD student, found his niche in ...