When they inserted human HARE5 into chimpanzee cells, they observed the same pattern: increased radial glial proliferation and faster maturation. Looking closer, the researchers pinpointed four ...

More information: Jing Liu et al, A human-specific enhancer fine-tunes radial glia potency and corticogenesis, Nature (2025). DOI: 10.1038/s41586-025-09002-1 ...

(1) Claim of disorganized radial glial fibers lacks quantifications. - On page 11, the authors claim that knockdown of Abba lead to changes in radial glial morphology observed with vimentin staining.

Called radial-glia-like cells, they give rise to neuronal progenitors that ultimately differentiate into new neurons. Further experiments revealed that radial-glial-like cells, which express IFN-γ ...

Radial glial cells (RGCs) are abundant stem-like non-neuronal progenitors that are important for adult neurogenesis and brain repair, yet little is known about their regulation by neurotransmitters.

They observed that the altered genes associated with ASD risk were predominant in undifferentiated radial glial cells. However, a gross change in the cell composition was not observed, implying that ...

Radial glial cells in the VZ were labeled with GFP on E14. GFP-positive cells were isolated 0.6–4 days later. (j) Expression of Ncan mRNA in GFP-labeled cells isolated on the indicated days after in ...

A clamp-and-ratchet microstructure based on poly crystalline silicon (polysilicon) microelectromechanical systems (MEMS) technology has been designed to exert mechanical tension along radial glial ...

Scientists from the University of California San Diego School of Medicine and Rady Children’s Institute for Genomic Medicine now unveil the role of a protein in human gyrification, establishing ...

But the organoids made from patient cells were highly disorganized and showed disrupted radial glial fibers. In the developing brain, these progenitor cells – which give rise to neurons and glia – ...

Radial glial cells (RGCs) are a population of highly polarized progenitors giving rise to neurons and glia (7). Their uniform radial orientation provides both the source of progenitor neurons as well ...