Rheumatoid arthritis (RA) is the most common form of chronic inflammatory arthritis, characterized by synovitis and ...

However, overexpression of Suv39h1 showed the opposite result.Mechanistically,down-regulation of Suv39h1 can relieve transcriptional inhibition of H3K9me3 on SIRT1, and promote mitochondrial autophagy ...

This review summarizes the correlation between gut microbiota and depression and provides new pathways for effective treatments of depression.

The SIRT1–FXR pathway was firstly proposed to participate in VPA-induced hepatotoxicity. FXR has been recognized as a major bile acid sensor and an important regulator of bile acid synthesis, ...

It may activate certain longevity pathways, such as AMPK and SIRT1, which are associated with increased cellular health and improved metabolic health. Overall, we believe Nutriissa Urolithin A is ...

The effects of SIRT1 activation were studied both in vitro and in vivo. Results MDD aggravated DSS-induced colitis clinically, endoscopically and histologically. MDD activated ER stress pathways, with ...

primarily via the activation of key signaling pathways such as AMP-activated protein kinase (AMPK) and sirtuin 1 (SIRT1). IF not only facilitates fatty acid oxidation and improves metabolic health, ...

Contrary to the belief that the path to sustainable development is increasingly out of reach, the results show that humankind has a variety of pathways to depart from its current unsustainable ...

The alternative complement pathway plays a key role in the pathogenesis of IgA nephropathy. Iptacopan specifically binds to factor B and inhibits the alternative pathway. In this phase 3 ...