Legendary California pharmacy Central Drug Store will be closing its doors for the last time on Tuesday after 117 years.

Central Drug Store in the Excelsior District will be closing its doors on July 15 after over 100 years. Owner Jerry Tonelli announced he will be retiring.

After 116 years, 5 plus owners and 60 plus years of family business, Jerry Tonelli says goodbye to the Excelsior legacy drugstore.

Central Drug Store, a community staple in San Francisco's Excelsior District since 1908, will permanently shut down at the end of the day on July 15, 2025.

After more than a century, the Central Drug Store in San Francisco is closing its doors as the owner takes a well-deserved break.

Jerry Tonelli, the owner of Central Drug Store in the Excelsior District, recalls there were hundreds of neighborhood pharmacies around the city in the 1970s.

The closure comes as Central Drug Store owner Jerry Tonelli announced his retirement after almost 50 years. The Tonelli family purchased and assumed ownership of Central Drug Store in 1965.

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