Mass General Brigham attributed the layoffs to an expected budget shortfall of $250 billion over the next two years.

Facing rising costs and hoping to make its sprawling network more efficient, the state’s largest private employer aims to cut payroll costs by over $200 million.

Nonprofit giant Mass General Brigham (MGB) will be laying off numerous non-clinical employees to close major budget shortfalls. | The major nonprofit system declined to put a number on the cuts and consolidations,