Tipoff is set for 10:30 p.m. ET from Crypto.com Arena in Los Angeles, Calif. The Lakers are favored by 3.5 points in the latest Spurs vs. Lakers odds, according to the SportsLine consensus. The over/under is 220.5 points. Before entering any Lakers vs. Spurs picks, you'll want to see the NBA predictions from the model at SportsLine.

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On top of the mismatch on both ends, too, the Spurs have tumbled down the ranks in rebounding rate as the Lakers have climbed out of the gutter — so if San Antonio continues to struggle for offense it likely won’t be afforded many second chances.