More than 400 million years ago, renin first appeared in organisms, 3 and renin is often seen as the first hormone discovered. Shortly before the 20th century, Tigerstedt and Bergman showed that ...

Previous clinical studies have reached a similar conclusion with regard to the predominance of Th1-type immune responses in graft arteriosclerosis by analyzing patient samples other than diseased ...

Gencer B, Djousse L, Al-Ramady OT, Cook NR, Manson JE, Albert CM. Effect of long-term marine ɷ-3 fatty acids supplementation on the risk of atrial fibrillation in randomized controlled trials of ...

Obesity is a significant risk factor for heart failure (HF) development, particularly HF with preserved ejection fraction and as a result, many patients with HF also have obesity. There is growing ...

Cardiac function is highly dependent on the well-orchestrated interplay between different cardiac cells within their specific tissue microenvironment. Cardiac fibroblasts represent ≈10% to 20% of all ...

This is more important, as the number of migrants is expected to further increase in the next decade. According to the United Nations estimate, there were about 281 million international migrants ...

Abstract Mammalian physiology and cellular function are subject to significant oscillations over the course of every 24-hour day. It is likely that these daily rhythms will affect function as well as ...

Graphical Abstract Alzheimer disease (AD) is the leading cause of clinically diagnosed dementia, with vascular contributions to cognitive impairment and dementia being the second leading cause of ...

Abstract IL (Interleukin)-17A is a key inflammatory mediator contributing to chronic tissue inflammation. The present study sought to determine whether IL-17A plays a role in regulating ...

Over the past 3 decades, raised BP has transitioned from a significant burden in high-income countries (HICs) to one that is now highly prominent in low- and middle-income countries (LMICs) including ...

Conclusions Compared with cardiac magnetic resonance, 3D‐ STE can evaluate biventricular functions of transplanted hearts accurately; 3D‐biventricular mechanical functions are reduced even in ...

Introduction Valvular heart disease represents a major public health problem worldwide. The incidence of valvular heart disease increases with age, and it is estimated that ≈15% of the population >75 ...