Prostate cancer (PCa) is the second most frequently occurring cancer and the fifth leading cause of cancer mortality among men worldwide in 2022 (Bray et al, 2024).Androgen receptor (AR) is considered ...

Rheumatoid arthritis (RA) is associated with heart and lung dysfunction. Current therapies fail to attenuate such complications. Here, we identify formyl-peptide receptor type 2 (FPR2) as a ...

N6-methyladenosine (m 6 A) exerts many of its regulatory effects on eukaryotic mRNAs by recruiting cytoplasmic YT521-B homology-domain family (YTHDF) proteins. Here, we show that in Arabidopsis ...

We demonstrate that TP53 deficiency in AML cells confers resistance to CAR T-cell therapy by inducing CAR T-cell dysfunction. We propose a model in which difficult-to-kill TP53-mutant AML cells ...

Neural stem cells (NSCs) in the mammalian brain decline rapidly with age, leading to impairment of hippocampal memory function in later life. However, the relationship between epigenetic remodeling ...

The effect of the DNMT3A R882 H mutation in a pre-leukaemic setting is not well understood. The murine homologue of the R882H mutation is R878H, and Dnmt3a R878H mouse models (Dai et al, 2017; Liao et ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Misfolding and aggregation of alpha-synuclein ...

ADHD is a prevalent neurodevelopmental disorder characterized by predominant symptoms in the domains of inattention, hyperactivity, and impulsivity, either individually or combined, and primarily ...

CD4 + T cells play a critical role in antiviral humoral and cellular immune responses. We have previously reported that subcutaneous lymphocytic choriomeningitis virus (s.c. LCMV) infection is ...

Multiple methods have been developed to study PPIs (Meyerkord and Fu, 2015), but all have limitations for the study of structure-specific interactomes.Affinity purification coupled to mass ...

Recently, we were able to show that both SARS-CoV-2 infection and mRNA vaccination prime human monocyte-derived macrophages for potent secretion of pro-inflammatory cytokines following restimulation ...

Haploinsufficiency of the progranulin (PGRN)‐encoding gene (GRN) causes frontotemporal lobar degeneration (GRN‐FTLD) and results in microglial hyperactivation, TREM2 activation, lysosomal dysfunction, ...