A total of 2516 participants underwent randomization; 1797 (71.4%) completed the trial. Of 2421 participants in the full analysis population (1209 assigned to the albuterol–budesonide group and ...

Each year, millions of pulmonary nodules are identified incidentally or through lung cancer screening, and many involve biopsy to distinguish cancer from benign processes. Both navigational ...

In this editorial, the authors describe the foundations of an N-of-1 gene-editing study to treat an infant with a urea-cycle disorder. 2 Department of Chemistry and Biochemistry, University of ...

Nerandomilast (BI 1015550) is an orally administered preferential inhibitor of phosphodiesterase 4B with antifibrotic and immunomodulatory properties. Nerandomilast has been shown to slow the ...

In this open-label trial with a 2-by-4 factorial design, we randomly assigned children with HIV who had first-line treatment failure to receive second-line therapy with tenofovir alafenamide ...

Multiple sclerosis is the most common cause of progressive neurologic disability in young adults. There had been no treatments for the disease, except for glucocorticoids, which were used for more ...

Nerandomilast (BI 1015550) is an orally administered preferential inhibitor of phosphodiesterase 4B with antifibrotic and immunomodulatory effects. In a phase 2 trial involving patients with ...

Dr. Margaret B. Mitchell (Otolaryngology): A 29-year-old woman was admitted to this hospital because of sore throat and peritonsillar swelling and bleeding. The patient had been well until 7 weeks ...

Sarcoidosis, a granulomatous disease that affects the lungs and other organs, has a variable course. Although spontaneous resolution of sarcoidosis occurs in some patients, half the patients with ...

Narcolepsy type 1 is a disorder of hypersomnolence caused by a loss of orexin neurons, which results in low orexin levels in the brain. In this phase 2, randomized, placebo-controlled trial ...

Pulmonary nodules are detected in more than 1.5 million U.S. residents every year. Nodules are identified incidentally on at least 20% of all diagnostic chest computed tomographic (CT) scans and ar ...

A 68-year-old woman presented to the emergency department with dizziness and shortness of breath with exertion.… Each interactive case presents an evolving patient history and a series of ...