The steroidogenic enzyme 3β-hydroxysteroid dehydrogenase type 1 (3βHSD1) correlates with tumor aggressiveness, and its inhibitors, biochanin-A (BCA) and the related analogs, have shown antitumor ...

Recent reports suggest that the US administration plans to eliminate the Environmental Protection Agency’s (EPA’s) Office of Research and Development (ORD) (1, 2). Most staff would be cut, with ...

Vibrio cholerae, known for its pathogenicity in humans, is most commonly a marine microbe that forms biofilms on chitin particles, which it can consume as a source of carbon and nitrogen. Upon ...

Maintenance of pH within membranous organelles is crucial for cellular processes such as posttranslational modifications, ligand–receptor interactions, and proteostasis. The precise mechanisms that ...

Sorting cells with target metabolic functions from a mutant pool exhibiting substantial genetic diversity is often the rate-limiting step in synthetic biology. Here, we developed a label-free, ...

Natural ice plays salient roles in making the Earth habitable and sustainable. Previously overlooked, its role in chemical processes is now of emerging interest, particularly due to the freeze ...

Greening immediately after etiolated-seedling’s emergence from the soil is critical for plants to initiate their autotrophic life cycle through photosynthesis. The greening process relies on a complex ...

Excess amounts of saturated fatty acids (FAs) are toxic to organisms, a condition termed lipotoxicity, which is often accompanied by pleiotropic cellular and tissue dysfunction. Here, we show that ...

Melanocyte development involves key pathways that are often recapitulated during melanoma initiation, highlighting the importance of understanding these regulatory processes. Our study identifies ...

Recent experiments have challenged the belief that glial cells, which compose at least half of brain cells, are just passive support structures. Despite this, a clear understanding of how neurons and ...

As AI tools become increasingly prevalent in workplaces, understanding the social dynamics of AI adoption is crucial. Through four experiments with over 4,400 participants, we reveal a social penalty ...

Final body size at developmental maturity often correlates with maximum lifespan (10 – 13). For instance, smaller individuals within a species often live longer than larger ones (11). In contrast, the ...