There are highs and lows every week in college football. The winners and losers for Week 4 start with Southern California's loss to Michigan.

Pretty much every college football analyst expected Michigan football to lose to USC on Saturday, but they play the games for a reason. With Alex Orji at the helm as the starting quarterback for the first time,

No. 18 Michigan inflicted a pair of significant blows in the first half against No. 11 USC on Saturday, taking a 14-3 lead into the break behind stingy defense and explosiveness in its run game. Kalel Mullings busted a 53-yard touchdown run on the Wolverines' third possession to open the scoring after the teams traded early punts.