Amy Schumer got brutally honest about the pros and cons she experienced while taking popular weight-loss drug Ozempic. On the Wednesday, January 29, installment of The Howard Stern Show, the actress revealed she took the medication "almost three years ago.

Wegovy is a GLP-1 agonist containing semaglutide, the same active ingredient as Ozempic. While both medications share this ingredient, they are approved for different purposes. Ozempic is primarily used for managing type 2 diabetes, whereas Wegovy is specifically approved for weight loss.

Some outcomes, like reduced risk of cardiovascular disease and increased chance of nausea, were expected. But others took researchers by surprise.

Amy Schumer recalled feeling so nauseous and lethargic after trying Ozempic three years ago that she became basically “bedridden.” In an interview with Howard Stern Wednesday, Schumer explained that she has a specific gene,

Once upon a time, Amy Schumer was one of the countless stars falling in line for the Ozempic craze, but, despite losing 30 pounds with the help of the Type 2 diabetes drug, the comedian had an overall "horrible experience" with it.

Amy Schumer’s experience on Ozempic was no laughing matter. The actress and comedian, 43, appeared on “The Howard Stern Show” on Wednesday and recalled how sick she got from taking the medication that makes you lose weight.