FTO Gene - GeneCards | FTO Protein | FTO Antibody
Oct 1, 2024 · FTO is a protein coding gene that demethylates RNA and regulates fat mass and energy homeostasis. It is associated with obesity, type 2 diabetes, and some rare diseases. Learn more about its function, pathways, products, and variants.
Fat mass and obesity-associated (FTO) protein regulates adult ...
Jul 1, 2017 · Fat mass and obesity-associated gene (FTO) is a member of the Fe (II)- and oxoglutarate-dependent AlkB dioxygenase family and is linked to both obesity and intellectual disability. The role of FTO in neurodevelopment and …
FTO and obesity: mechanisms of association - PubMed
This review summarizes the recent progress about biological functions of FTO through disease-association studies as well as the data from in vitro and in vivo models, and highlights the biochemical features of FTO that might be linked to obesity.
Crystal structure of the FTO protein reveals basis for its substrate ...
Apr 7, 2010 · FTO protein is a DNA/RNA demethylase, and mice lacking it are abnormally lean. Now the crystal structure of human FTO in complex with the mononucleotide 3-meT has been determined.
FTO genotype, dietary protein intake, and body weight in a …
Feb 20, 2018 · We investigated whether dietary protein intake modifies the association between FTO variant rs1558902 and body mass index (BMI) and waist circumference in young adults (n = 1491) from the cross-sectional Toronto Nutrigenomics and Health Study.
Emerging Role and Mechanism of the FTO Gene in Cardiovascular …
The fat mass and obesity–associated (FTO) protein regulates the initiation and progression of cardiovascular diseases. FTO can catalyze the m6A demethylation of target mRNA and affect its nuclear export, degradation, stability, and translation, thus affecting the initiation and progression of cardiovascular diseases such as myocardial ...
FTO in cancer: functions, molecular mechanisms, and therapeutic ...
Mar 25, 2022 · Discovered as the first RNA m6A demethylase, the fat mass and obesity-associated protein (FTO) is frequently dysregulated and plays important roles in various types of cancers. Targeting FTO holds promising therapeutic significance via suppressing tumor growth, potentiating immunotherapy, and attenuating drug resistance.
FTO in cancer: functions, molecular mechanisms, and therapeutic ...
Jul 1, 2022 · Fat mass and obesity-associated protein (FTO) mediates signal transducer and activator of transcription 3 (STAT3)-derived resistance of breast cancer to doxorubicin
Fat mass and obesity-associated (FTO) protein regulates adult ...
Jul 1, 2017 · To determine whether FTO plays any role in adult neurogenesis, we first examined the expression of FTO in mouse brain using immunofluorescence staining. FTO protein was detected in Nestin + aNSCs (Fig. 1A). Consistent with previous studies (13,16), we also found that FTO is highly expressed in NeuN + mature neurons (Fig. 1B).
The Fat Mass‐ and Obesity‐Associated (FTO) Gene to Obesity: …
Fto mRNA and protein levels are dramatically downregulated by total amino acid deprivation in mouse hypothalamic N46 cells, mouse embryonic fibroblasts, and human HEK293 cells.
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